Fig. 3.

Freehand SPECT–ultrasound in action during sentinel lymph node aspiration biopsy. a Freehand SPECT acquisition using a handheld gamma camera as nuclear detector, in a breast cancer patient. b Placement of the needle for aspiration biopsy based on freehand SPECT–US image. c B-mode image of axilla of patient showing at least one lymph node. d Freehand SPECT–US combination highlights the radioactive SLN by making it more prominent

(Figure reproduced with permission from [19]—Wendler. Intraoperative 3D nuclear imaging and its hybrid extensions)