Table 4.

Clinical studies using hybrid gamma–NIR guidance with ^99mTc and ICG for SLNB ordered by year of publication

Cancer types	Intraoperative detection	Study pop.	Study location	Year	Refs
Pelvic Prostate carcinoma	G N: Europrobea G I: Sentinellab (ex vivo) NIR I: Fluorescence laparoscopec	11	Dutch Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands	2011	[33]
H&N Squamous cell carcinoma	G N: Neoprobed G I: Sentinellab NIR I: Photodynamic Eyee	14	Dutch Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands	2012	[43]
Pelvic Prostate cancer	G N: Neoprobe 2000a NIR I: (*) Laparoscopic system from component partsc	26	Paracelsus Medical University of Salzburg, Austria	2012	[32]
H&N Melanoma	G N: Neoprobed G I: Sentinellab NIR I: Photodynamic Eyee	11	Dutch Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands	2012	[40]
Breast	G N: Europrobef NIR I: Mini-FLAREg	32	Leiden University Medical Centre, Netherlands	2013	[31]
Inguinal Vulvar cancer	G N: Neoprobed G I: Sentinellab NIR I: Photodynamic Eyee	15	Dutch Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands	2013	[34]
Misc. Penile carcinoma, oral cavity tumours, melanoma	G N: Neoprobed G I: Sentinellab NIR I: Photodynamic Eyee	20	Dutch Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands	2013	[36]
Inguinal Penile squamous cell carcinoma	G N: Neoprobed G I: Sentinellab NIR I: Photodynamic Eyee	65	Dutch Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands	2014	[37]
H&N Melanoma, oral cavity squamous cell carcinoma	G N: Neoprobed G I: Sentinellab NIR I: Photodynamic Eyee	25	Dutch Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands	2014	[44]
H&N Melanoma, squamous cell carcinoma, Merkel cell carcinoma, sweat gland carcinoma	G N: Unknown NIR I: (*) Fluobeamh and modified lighti	40	University Medical Center Klinik für Dermatologie, Essen, Germany	2015	[41]
Inguinal Vulvar cancer	G N: Unknown NIR I: Mini-FLAREg	12	Leiden University Medical Centre, Netherlands	2015	[35]
Misc. Melanoma (H&N, trunk, extremities)	G N: Neoprobed G I: Sentinellab NIR I: Photodynamic Eyee	104	Dutch Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands	2015	[42]
H&N Oral cavity squamous cell carcinoma	G N: Neo2000j NIR I: Photodynamic Eyee	16	Ehime University Hospital, Japan	2015	[45]
Misc. H&N, penile	G & NIR N: (*) Opto-nuclear probe prototypef	9 (in vivo)	Dutch Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands	2015	[38]
Inguinal Penile cancer	G N & NIR I: (*) Europrobe 2f and VITOMc G I & NIR I: (*) Sentinellab and VITOMc	11	Dutch Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands	2016	[39]
Misc. Penile, oral squamous cell carcinoma, melanoma (H&N, trunk, extremities)	G N: Unknown G I: Unknown NIR I: (*) Modified and commercial Photodynamic eyee	27	Dutch Cancer Institute–Antoni van Leeuwenhoek Hospital, Amsterdam, Netherlands		[50]

Intraoperative detection of gamma photons (G) has been separated into imaging (I) and non-imaging (N). Detection devices used are referenced as footnotes. A (*) indicates that a device that is not commercially available was used in the study. When study location was not explicitly stated, that of the corresponding author has been used

^aEuroprobe, London, UK

^bOncovision, Valencia, Spain

^cKarl Storz, Tuttlingen, Germany

^dJohnson & Johnson Medical, Germany

^eHamamatsu Photonics, Hamamatsu, Japan

^fEurorad S.A, Eckbolsheim, France

^gCuradel, Marlborough, USA

^hFluoptics, Grenoble, France

ⁱLED DayLite Twin Beam, Designs for Vision, New York, USA, modified with a low pass filter

^jNeoprobe Corporation, USA