Table 1.

Estimates of mixed effect model for the behavioral parameters measured during Ayahuasca exposure.

						Behavioral parameters
	Average speed			Total distance traveled			Freezing			Distance from bottom
Explanatory variable	Chi-squared	p-Value		Chi-squared	p-Value		Chi-squared	p-Value		Chi-squared	p-Value
60 min time course	8.41	0.004		8.44	0.003
Doses	19.91	0.0005		19.93	0.0005
Pairwise comparison	lsmeans ± SEM	t-Value	p-Value	lsmeans ± SEM	t-Value	p-Value	lsmeans ± SEM	t-Value	p-Value	lsmeans ± SEM	t-Value	p-Value
Dose 0.0 vs. dose 0.1	0.03 ± 0.05	0.61	0.97	5.31 ± 0.00	0.61	0.99	0.03 ± 3.60	0.01	1.00	-2.34 ± 0.81	-2.86	0.04
Dose 0.0 vs. dose 0.5	-0.04 ± 0.05	-0.84	0.91	-7.14 ± 0.00	-0.83	0.92	-4.61 ± 4.25	-1.08	0.81	2.87 ± 0.81	3.54	0.00
Dose 0.0 vs. dose 1.0	-0.15 ± 0.05	-2.88	0.04	-2.47 ± 0.00	-2.88	0.05	-14.4 ± 4.01	-3.58	0.00	2.10 ± 1.18	1.77	0.03
Dose 0.0 vs. dose 3.0	-0.14 ± 0.05	-2.77	0.03	-2.37 ± 0.00	-2.77	0.04	-17.6 ± 3.44	-5.11	< 0.00	3.71 ± 0.76	4.86	0.00
Dose 0.1 vs. dose 0.5	-0.07 ± 0.05	-1.43	0.60	-1.24 ± 0.00	-1.44	0.61	-4.64 ± 4.48	-1.03	0.83	5.21 ± 0.91	5.69	<0.00
Dose 0.1 vs. dose 1.0	-0.18 ± 0.05	-3.44	0.01	-3.00 ± 0.00	-3.42	0.01	-14.4 ± 4.26	-3.38	0.01	4.44 ± 1.25	3.53	0.00
Dose 0.1 vs. dose 3.0	-0.17 ± 0.05	-3.33	0.01	-2.90 ± 0.00	-3.33	0.01	-17.6 ± 3.73	-4.73	0.00	6.05 ± 0.87	6.92	<0.00
Dose 0.5 vs. dose 1.0	-0.10 ± 0.05	-2.04	0.25	-1.76 ± 0.00	-2.04	0.26	-9.79 ± 4.82	-2.03	0.26	-0.77 ± 1.25	-0.61	0.97
Dose 0.5 vs. dose 3.0	-0.10 ± 0.05	-1.93	0.31	-1.66 ± 0.00	-1.93	0.32	-13.0 ± 4.36	-2.98	0.03	0.84 ± 0.86	0.96	0.86
Dose 1.0 vs. dose 3.0	0.005 ± 0.05	0.11	1.00	9.69 ± 0.00	0.11	0.99	-3.24 ± 4.13	-0.78	0.93	1.61 ± 1.22	1.31	0.68

Dose values are expressed in mg/L.