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. 2017 Jul 28;10:228. doi: 10.3389/fnmol.2017.00228

Figure 4.

Figure 4

Increased hippocampal neurodegeneration in miR-155 KO mice after CCI. Degenerating neurons were stained with fluoro-jade C (FJC; green) and DAPI (blue) 3 days after 1.0-mm CCI in the brains of WT (n = 5) and miR-155 KO (n = 6) mice. (A) Representative images from the ipsilateral DG. (B) Quantification of FJC positive cells in the DG. The mean ± SEM is shown. *P < 0.05 by Student’s T-test. (C) Representative images of full-length and cleaved caspase 3 and beta-actin (Actin) analyzed by Western blot in WT and miR-155 KO ipsilateral hippocampi 3 days after 1.0-mm CCI. (D) Quantification of the percentage of cleaved Caspase 3 relative to full-length Caspase 3. The mean ± SEM are shown, (n = 4).