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. 2016 Feb 17;66(6):1083–1094. doi: 10.1136/gutjnl-2015-310971

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This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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Proposed antinociceptive mechanism by which α-conotoxin Vc1.1 activates γ-aminobutyric acid receptor B (GABA_BR). Vc1.1 activates GABA_BR expressed on human dorsal root ganglion (DRG) neurons and on colonic afferent endings resulting in Gβγ and c-Src kinase-mediated inhibition of Ca_V2.2 and Ca_V2.3 and subsequent inhibition of neuronal excitability. Modified from Adams et al.¹⁴