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. 2017 Jul 21;5(14):e13332. doi: 10.14814/phy2.13332

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© 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Fibrosis assessed as percent collagen content of the total myocardium in PAH‐ rats. There is significantly more fibrosis in the right ventricular free wall and anterior hinge‐point regions in PAH rats compared with shams. Fibrosis in the LV anterior hinge‐point region in PAH‐rats is higher than shams. *P < 0.05, **P < 0.01. The TGF β‐blocker SB431542 reduced fibrosis in the free wall and anterior hinge‐point of the LV. ^$ P < 0.05, ^$$ P < 0.01. Data are presented as mean (SD), Sham: n = 8, PAH: n = 5 and TGF β‐ blocker: n = 6. RV, right ventricle; LV, left ventricle; ant, anterior; post, posterior; HP, hinge‐point.