Table 2.
Echocardiography results from both ventricles by 2D measurements, and m‐mode
| Echocardiography | Sham rabbits (n = 6) | PAB (n = 14) | Sham rats (n = 8) | PAH (n = 5) | TGFβ‐blocker (n = 6) |
|---|---|---|---|---|---|
| 2D measurements | |||||
| LV end‐systolic eccentricity index | 1.17 (0.24) | 1.21 (0.23) | 1.11 (0.04) | 2.12 (0.59)§ | 2.43 (0.84)∧ |
| LV end‐diastolic eccentricity. Index | 1.15 (0.26) | 1.24 (0.29) | 1.08 (0.02) | 1.92 (0.33)§§ | 1.75 (0.43)∧ |
| RV‐FAC (%) | 35 (13) | 34 (17) | 43 (3.2) | 21.7 (5.3)§§§ | 40.7 (7.4)### |
| M mode | |||||
| LV EDD (cm) | 1.3 (0.14) | 1.1 (0.18) | 0.84 (0.1) | 0.57 (0.11)§ | 0.46 (0.08)# |
| LV ES (cm) | 0.9 (0.12) | 0.8 (0.15)* | 0.55 (0.1) | 0.38 (0.09)§§ | 0.3 (0.07) |
| LV FS (%) | 30 (6) | 31 (9) | 38 (10) | 33 (8) | 38 (9) |
| LV EF (%) | 61 (10) | 62 (14) | 68.7 (8.5) | 62.2 (10.7) | 73 (11) |
| TAPSE (cm) | 0.4 (0.09) | 0.3 (0.08)* | 0.26 (0.03) | 0.14 (0.05)§§ | 0.22 (0.07)## |
| PA band gradient | 4 (1) | 19 (15)** | — | — | — |
Results are presented as mean (SD). Sham rabbits versus PAB rabbits: *P < 0.05, **P < 0.01. Sham rats versus PAH rats: § P < 0.05, §§ P < 0.01, and §§§ P < 0.0001. PAH versus TGFβ # P < 0.05, ## P < 0.01, ### P < 0.001. Sham rats versus TGFβ ∧ P < 0.01. PAB, Pulmonary artery banding; PAH, pulmonary arterial hypertension; ecc, eccentricity; EDD, end‐diastolic diameter; ES, end‐systolic diameter; FS, fraction shortening; EF, ejection fraction, TAPSE, tricuspid annular plane systolic excursion.