Skip to main content
. 2017 Jul 1;5(14):e13351. doi: 10.14814/phy2.13351

Figure 1.

Figure 1

17β‐Estradiol increases the depolarization‐induced whole‐cell BK outward currents in freshly isolated detrusor smooth muscle (DSM) cells. (A) Representative original recordings illustrating the depolarization‐induced whole‐cell outward currents in the absence (control) and in the presence of 17β‐estradiol (100 nmol/L). (B) The current–voltage relationship curve summarizes the stimulatory effects of 17β‐estradiol on the whole‐cell outward currents (n = 12, N = 8; *P < 0.05). (C) Representative original recordings illustrating the depolarization‐induced whole‐cell outward currents in the presence of paxilline (1 μmol/L) alone and in the presence of both paxilline (1 μmol/L) and 17β‐estradiol (100 nmol/L). (D) The current–voltage relationship curve summarizes the lack of stimulatory effects of 17β‐estradiol on the whole‐cell outward currents in the presence of 1 μmol/L paxilline (n = 6, N = 6; P > 0.05).