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. 2017 Jul 1;5(14):e13351. doi: 10.14814/phy2.13351

Figure 4.

Figure 4

17β‐Estradiol hyperpolarizes the resting membrane potential (RMP) in detrusor smooth muscle (DSM) cells. (A) A representative trace of an RMP recording in current‐clamp mode illustrating the hyperpolarizing effects of 17β‐estradiol (100 nmol/L) in an isolated human DSM cell. (B) Summary data illustrating the hyperpolarizing effects of 17β‐estradiol on the human DSM cell RMP (n = 11, N = 9; *P < 0.05). (C) A representative trace of an RMP in current‐clamp mode demonstrating that when the BK channels were blocked with 1 μmol/L paxilline, 17β‐estradiol (100 nmol/L) did not cause membrane hyperpolarization in DSM cells. (D) Summary data illustrating that 17β‐estradiol had no effect on the human DSM cell RMP in the presence of 1 μmol/L paxilline (n = 8, N = 5; P > 0.05).