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. 2017 Jul 1;5(14):e13351. doi: 10.14814/phy2.13351

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© 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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17β‐Estradiol inhibits spontaneous phasic contractions of human detrusor smooth muscle (DSM)‐isolated strips. (A) Representative original recordings illustrating the concentration‐dependent inhibitory effects of 17β‐estradiol (100 nmol/L‐1 μmol/L) on spontaneous phasic contractions of isolated DSM strips in the absence (A) or presence (B) of paxilline (1 μmol/L). (C and D) Summary data illustrating the inhibitory effects of 17β‐estradiol on the amplitudes and muscle force of spontaneous phasic contraction of DSM‐isolated strips in the absence (n = 8, N = 5) and presence of 1 μmol/L paxilline (n = 5, N = 5; *P < 0.05).