Figure 1. Waterfall plots showing mean change from baseline in tumour size in the per-protocol population.

Change in tumour size recorded as smallest sum of diameters. Objective response was either a complete or partial response. Dotted line represents the threshold for partial response. *Patients who are still on treatment as of data cutoff (April 18, 2014). (A) Patients who have never received a multikinase inhibitor (cohort 1). (B) Patients previously treated with a multikinase inhibitor (cohort 2). One patient in cohort 2 did not have a post-baseline tumour assessment because they died within the first two cycles of treatment.