Table 2.
Acute toxicities of the Gambierdiscus and Fukuyoa extracts, by i.p. injection and by gavage.
| Cawthron ID | Organism | Source | LD50 by i.p. Injection (mg/kg) | LD50 by Gavage (mg/kg) |
|---|---|---|---|---|
| CAWD 213 | G. pacificus | Rarotonga, Cook Islands | 0.50 (0.35–0.70) | >400 * |
| CAWD 227 | G. pacificus | Rarotonga, Cook Islands | 0.40 (0.28–0.53) | >400 * |
| C14 CI | G. pacificus | Rarotonga, Cook Islands | 0.94 (0.79–1.00) | >320 * |
| CAWD 233 | G. honu | Rarotonga, Cook Islands | 0.20 (0.15–0.24) | 79.0 (40.7–98.2) |
| CAWD 242 | G. honu | N Meyer Is., Kermadec Islands | 0.20 (0.07–0.23) | 100 (74.9–114) |
| S 8 xii | G. australes | Rarotonga, Cook Islands | 0.50 (0.25–0.87) | 26.8 (25.1–32.0) |
| CAWD 149 | G. australes | Rarotonga, Cook Islands | 0.37 (0.32–0.50) | 40.0 (29.6–47.4) |
| S4G | G. australes | Rarotonga, Cook Islands | 0.42 (0.40–0.50 | 33.8 (32.0–40.0) |
| S5(6)GC2a | G. australes | Rarotonga, Cook Islands | 0.53 (0.50–0.63) | 50.0 (26.1–61.9) |
| CAWD 244. | G. australes | N Meyer Is., Kermadec Islands | 0.50 (0.35–0.66) | 63.0 (47.7–89.7 |
| S9a | G. australes | Rarotonga, Cook Islands | 1.06 (1.00–1.26) | 84.2 (79.0–100) |
| CAWD 246 | G. australes | Rarotonga, Cook Islands | 0.20 (0.16–0.25) | 20.0 (16.0–25.3) |
| CAWD 232 | G. cheloniae | Rarotonga, Cook Islands | 0.32 (0.221–0.426) | 118 (100–126) |
| CAWD 236 | G. cheloniae | Rarotonga, Cook Islands | 1.58 (1.11–2.09) | 268 (251–320) |
| CAWD 238 | F. paulensis | Northland, New Zealand | 10.0 (9.53–17.9) | >790 * |
| CAWD 237 a | G. carpenteri | New South Wales, Australia | 10.0 (5.1–12.4) | >158 * |
| CAWD 212 | G. polynesiensis | Rarotonga, Cook Islands | 1.88 (1.58–2.00) | 3.20 (2.55–4.03) |
a The original code name for CAWD 237 was UTSMER9A3. * Insufficient material was available for determining the median lethal doses of these materials. The figures shown are the highest doses administered, none of which were fatal. Figures in brackets indicate 95% confidence intervals.