Table I.
Characteristics of HOTTIP studies included in the meta-analysis.
| Authors | Year | Country | Cancer type | Total no. | HOTTIPP detection method | Cut-off | Outcome | Survival analysis | HR estimate | (Refs.) |
|---|---|---|---|---|---|---|---|---|---|---|
| Quagliata et al | 2014 | Switzerland | HCC | 52 | RT-qPCR | Median | OS | Univariate | Survival curve | (12) |
| Ge et al | 2015 | China | HCC | 48 | RT-qPCR | Median | OS | Univariate | Survival curve | (14) |
| Zhang et al | 2015 | China | TSCC | 86 | RT-qPCR | Median | OS | Multivariate, univariate | Reported | (9) |
| Ren et al | 2015 | China | CRC | 156 | RT-qPCR | Median | OS | Multivariate, univariate | Reported | (11) |
| Li et al | 2015 | China | OSA | 68 | RT-qPCR | Mean | OS | Multivariate, univariate | Reported | (13) |
| Ye et al | 2016 | China | GC | 98 | RT-qPCR | Median | OS | Univariate | Survival curve | (10) |
HOTTIP, HOXA distal transcript antisense RNA; HR, hazard ratio; OS, overall survival; HCC, hepatocellular carcinoma; TSCC, tongue squamous cell carcinoma; CRC, colorectal cancer; OSA, osteosarcoma; GC, gastric cancer; RT-qPCR, reverse transcription-quantitative polymerase chain reaction.