Table 1. Enzyme Inhibition Efficacy of Compounds 1–6^a.

	IC50
	β-glucosidase		α-glucosidase
compd	GBA1	GBA2	GAA	GANAB
1	165 ± 4 nM	139 ± 60 nM	>100 μM	>100 μM
2	304 ± 5 nM	14 ± 1 nM	>100 μM	>100 μM
3	>100 μM	>100 μM	15 ± 2 μM	>100 μM
4	21 ± 1 μM	>100 μM	38 ± 3 nM	1.4 ± 0.1 μM
5	>100 μM	>100 μM	82 ± 1 nM	29 ± 2 nM
6	119 ± 9.8 μM	58 ± 4.5 μM	>100 μM	>100 μM

^aApparent IC₅₀ values for in vitro inhibition of GBA1, GBA2, GAA, and GANAB. Reported values are mean ± standard deviation from 3 technical replicates.