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. Author manuscript; available in PMC: 2017 Aug 18.
Published in final edited form as: Mol Membr Biol. 2016 Aug 18;33(1-2):1–11. doi: 10.1080/09687688.2016.1213432

Figure 3. Structural evolution of GGDPS inhibitors.

Figure 3

Small nitrogen-containing bisphosphonates are inhibitors of farnesyl diphosphate synthase (FDPS). Lipophilic bisphosphonates can inhibit the enzymes of farnesyl diphosphate metabolism, including GGDPS and squalene synthase. Branched bisalkyl bisphosphonates retain specificity for GGDPS. Non bisphosphonate inhibitors of GGDPS have also been identified.