Table 3. Simplified evaluation scheme treatment of reperfusion injury.
| Therapeutic
target |
Treatment | Route of
administration |
Result |
|---|---|---|---|
| Indeterminate | Hypothermia | IV | − |
| Hypothermia | Peritoneal | − | |
| MMTP | Delcasetrib | IV before reperfusion | − |
| TR040303 | IV before reperfusion | − | |
| Bendavia | IV before reperfusion | − | |
| Ciclosporin A | IV before reperfusion | + − | |
| Nitric oxide
signaling |
Nitrite sodium | IV | − |
| Nitrite sodium | Intracoronary | − | |
| Nitric oxide | Inhaled | − | |
| Pro-survival
kinase |
Copertide | IV | + |
| Exenatide | IV | + | |
| Indeterminate | Metoprolol | IV | + |
| Indeterminate | Post-conditioning | IC balloon inflations | + + − − |
| Indeterminate | RIC | Limb ischemia | + + + +
+ + + − |
+, one trial with positive results; −, one trial with negative results; IC, intracoronary; IV, intravascular; MMTP, mitochondrial permeability transition pore; RIC, remote ischemic conditioning.