Table 1.
Review of randomized trials comparing breast-conserving surgery (BCS) with or without adjuvant radiation (RT)
| Study name | Study dates | N | Median F/Ua (years) | % positive/unknown margins | Local recurrence | |
|---|---|---|---|---|---|---|
| No RT | RT | |||||
| NSABPb B-17 (5)† | 1985–1990 | 818 | 17.25 | 0% | 35.1% | 17.7% |
| EORTCc 10853 (4)† | 1986–1996 | 1010 | 15.8 | 16% | 31.0% | 18.0% |
| SweDCISd (6)‡ | 1987–1999 | 1067 | 17.5 | 20% | 32.0% | 20.0% |
| UK/ANZ DCISe (3)§ | 1990–1998 | 1030 | 12.7 | 0% | 19.4% | 7.1% |
†
15-year local recurrence rates
‡
20-year local recurrence rates
§
10-year local recurrence rates
a
Abbreviation: F/U, follow-up
b
Abbreviation: NSABP, National Surgical Adjuvant Breast and Bowel Project
c
Abbreviation: EORTC, European Organisation for Research and Treatment of Cancer
d
Abbreviation: SweDCIS, Swedish Ductal Carcinoma in Situ
e
Abbreviation: UK/ANZ DCIS, UK, Australia, and New Zealand Ductal Carcinoma In Situ