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. 2005 Feb 23;102(10):3811–3816. doi: 10.1073/pnas.0500195102

Fig. 5.

Fig. 5.

Progression of MWM deficit in AD11 mice. (a) Learning curves for WT and AD11 mice at the age of 7 months. The difference between WT and AD11 mice is significant (genotype, P < 0.001; time, P < 0.001). (b) Results of the probe trial at 7 months of age. The platform (located in the NE quadrant during learning) was removed. Both WT and AD11 mice spent significantly more time in the NE quadrant (P < 0.001). (c) Learning curves for AD11 and WT mice ages 9–10 months. The difference between WT and AD11 is significant (genotype, P < 0.01; time, P < 0.01). (d) Results of the probe trial at 9–10 months of age. The platform (located in the SW quadrant during learning) was removed. WT mice spent significantly more time in the SW quadrant, whereas AD11 mice did not show any significant preference for the SW quadrant (P < 0.001 and P > 0.05, respectively).