Table 4.

C‐Statistic Analyses for Multivariable Analyses Including Different Risk Factors With and Without IL‐34 as Predictors of the Primary End Point in HF Patients

	AUC‐ROC
	Total Cohort (n=510)	Non‐CKD (n=363)	CKD (n=147)
IL‐34	0.627 (0.572–0.682) (P<0.001)	0.574 (0.491–0.657) (P=0.082)	0.630 (0.540–0.720) (P=0.007)
Without IL‐34	0.827 (0.784–0.869) (P<0.001)	0.781 (0.707–0.855) (P<0.001)	0.724 (0.641–0.808) (P<0.001)
With IL‐34	0.837 (0.795–0.878) (P<0.001)	0.786 (0.716–0.857) (P<0.001)	0.768 (0.687–0.848) (P<0.001)
P value	0.364	0.784	0.033

Multivariable analysis with or without IL‐34 consists of several risk factors for the primary end point, including age, sex, body mass index, smoking status, history of DM, history of hypertension, hsCRP, NT‐proBNP, cystatin C, hemoglobin, albumin, and NYHA class. AUC‐ROC indicates area under the curve‐receiver operating characteristics; DM, diabetes mellitus; HF, heart failure; hsCRP, high‐sensitivity C reactive protein; IL, interleukin; NT‐proBNP, N‐terminal pro‐brain natriuretic peptide; NYHA, New York Heart Association.