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. 2017 Apr 5;6(4):e004965. doi: 10.1161/JAHA.116.004965

Figure 6.

Figure 6

Intracellular Ang‐II regulates fibroblast proliferation. A, [3H]Thymidine incorporation in atrial fibroblasts treated in parallel with medium alone; Ang‐II (100 nmol/L), alone or pretreated with PD123177 (1 μmol/L) and valsartan (1 μmol/L); and PD123177 (1 μmol/L) and valsartan (1 μmol/L) without Ang‐II. B, [3H]Thymidine incorporation in photolysed atrial fibroblasts treated with medium alone; cAng‐II (100 nmol/L); scrambled cAng‐II analog (100 nmol/L); cAng‐II plus extracellular PD123177 (1 μmol/L) and valsartan (1 μmol/L); and extracellular PD123177 (1 μmol/L) and valsartan (1 μmol/L) without cAng‐II. *P<0.05, **P<0.01, ***P<0.001 by 1‐way ANOVA with Bonferroni‐adjusted t test vs control (Ctl). N=4/group. Ang‐II indicates angiotensin II; DPM, disintegrations per minute; PD, PD123177; VAL, valsartan. All results are mean±SEM.