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. 2017 Apr 1;6(4):e005146. doi: 10.1161/JAHA.116.005146

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© 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Gene expression analysis of EPCs (CD34+) and HUVECs exposed to high glucose (HG) and normal glucose (NG). Human EPCs (CD34+) were exposed to NG (5.5 mmol/L) and HG (20 mmol/L) for 48 hours. A, Upregulation of apoptotic genes (both p53 and p21) was observed due to HG exposure. B, HUVECs showed upregulation of apoptotic (p53 and p21), platelet endothelial cell adhesion molecule 1 (PECAM‐1) and inflammatory (IL6) genes after 28 days of HG exposure compared with 7 and 14 days, indicating that HG effects are not fully apparent in HUVECs until 28 days. *P<0.05.