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. 2017 Apr 1;6(4):e005146. doi: 10.1161/JAHA.116.005146

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© 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Oxygen consumption rate of HUVECs exposed to normal glucose (NG) and high glucose (HG). HUVECs were exposed to NG (5.5 mmol/L) and HG (20 mmol/L) for 7, 14, and 28 days followed by oxygen consumption rate measurement during a mitochondrial stress test. A and B, No significant change in between NG and HG exposed cells was observed at day 7 and 14. C, Lower respiration rate of HUVECs was noted only after 28 days of high glucose exposure. Additives injected are indicated with arrows: a. Oligomycin‐1.1 μmol/L, b. FCCP‐2.08 μmol/L and c. Rot/AA‐0.5 μmol/L. These data demonstrate reduced oxygen consumption rate of mature endothelial cells (HUVECs) exposed to hyperglycemic environment for a prolonged time (28 days). These results are representative of 3 independent experiments. *P<0.05.