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. 2017 Apr 1;6(4):e005146. doi: 10.1161/JAHA.116.005146

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© 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Enhanced vascularization in hind limb of obese diabetic Leptin resistant (db/db) mouse model posttransplantation of p53KO and p21KO mouse EPCs. p53KO and p21KO mouse EPCs were transplanted to mouse (B6.BKS(D)‐Leprdb/J) right hind limb muscle postocclusion of femoral artery. A, Blood flow was measured by Laser Doppler Perfusion Imager (LDPI) system after surgery (3, 7, 10 days). No statistical difference was noted with delivery of p53KO (purple line) and p21KO (green line) EPCs, compared to WT (wild type; red line) and saline (blue line). B, Similarly, gene expression analysis data unable to show any improvement due to gene silencing. C, No statistical difference in the number of capillaries were observed when quadriceps was stained with CD31 antibody between operated and non‐operated side.