Figure 5.

Natriuretic peptide levels are influenced both by genetic factors and conditions that increase cardiac wall stress. Elevation in natriuretic peptides serves as a compensatory mechanism, resulting in vasodilation, natriuresis, and diuresis, with resultant decrease in blood pressure, sympathetic tone, aldosterone, fibrosis, and ventricular hypertrophy. Nevertheless, elevation in natriuretic peptides are markers of increased wall stress and predict adverse outcomes. LV indicated left ventricular; NPPB, B‐type natriuretic peptide gene G allele at rs198389.