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Voltage‐dependent gating for cardiac sodium channel in induced pluripotent stem‐cell–derived cardiomyocytes expressing with vinculin (VCL). A, There was no statistically significant difference in activation of cardiac sodium channel between each group. B, Under pH 7.0 conditions, D841H caused a significant repolarizing shift by 25.6 mV in inactivation of cardiac sodium channel compared to wild type (WT) at pH 7.4.
