Fig. 3.

Fifteen compounds significantly slowed the loss A4V, G85R, and G93A SOD1 dimer under aggregating conditions. (a) EDTA-induced loss of A4V dimer in the absence (solid black line) and presence of the top 100 compounds, as predicted by the docking calculation. The average of three trials is plotted for each compound; variation was <5%. The loss of WT was very slow under these conditions (dashed red line). (b) EDTA-induced loss of G85R dimer in the absence (solid black line) and presence of the 15 best inhibitors of A4V aggregation (see a). (c) EDTA-induced loss of G93A dimer in the absence (black line) in presence of the 15 best inhibitors of A4V aggregation. (d) EDTA-induced loss of WT dimer in the absence (black line) and presence of the 15 best inhibitors of A4V aggregation. Note the difference in the scale of the y axes.