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. 2017 Apr 5;6(4):e005556. doi: 10.1161/JAHA.117.005556

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© 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Changes in metabolite levels in microdialysates before (basal), during (stroke), and after (reperf.) transient (90 minutes) middle cerebral artery occlusion: (A) glucose, (B) lactate, (C) β‐hydroxybutyrate (BHB). Mice were kept on diets that were rich in carbohydrates (standard diet; Altromin), in triheptanoin (Trihept.), or in soybean oil (Soy) for 3 weeks. Data are concentrations that were calculated from 6 samples taken before, during, or after stroke and are mean±SD of 6 experiments. Statistics were calculated by 1‐way ANOVA and Tukey post‐test; **P<0.01 vs basal; ^# P<0.05; ^## P<0.01 vs stroke.