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. Author manuscript; available in PMC: 2017 Jul 28.
Published in final edited form as: Toxicol Appl Pharmacol. 2014 Mar 20;277(2):138–145. doi: 10.1016/j.taap.2014.03.009

Table 1.

Properties of antibiotics used in present study

Antibiotics Category Mechanism Spectrum Intestinal Absorption
Metronidazole nitroimidazole deactivation of critical enzymes narrow spectrum; anaerobic bacteria complete (>90%)
Ciprofloxacin fluoroquinolone inhibition of topoisomerase II and IV broad spectrum; gram-positive and negative well (>70%)
Aztreonam β-lactam inhibition of cell wall narrow spectrum; gram-negative poorly
Vancomycin glycopeptide inhibition of cell wall synthesis narrow spectrum; gram-positive poorly
Imipenem β-lactam inhibition of bacterial cell wall formation broad spectrum; gram-positive and negative poorly
Cephalothin β-lactam inhibition of bacterial cell wall formation broad spectrum; gram-positive and negative poorly
Neomycin aminoglycosides inhibition of protein synthesis in bacteria broad spectrum; excellent for gram-negative poorly