Table 1.
Properties of antibiotics used in present study
Antibiotics | Category | Mechanism | Spectrum | Intestinal Absorption |
---|---|---|---|---|
Metronidazole | nitroimidazole | deactivation of critical enzymes | narrow spectrum; anaerobic bacteria | complete (>90%) |
Ciprofloxacin | fluoroquinolone | inhibition of topoisomerase II and IV | broad spectrum; gram-positive and negative | well (>70%) |
Aztreonam | β-lactam | inhibition of cell wall | narrow spectrum; gram-negative | poorly |
Vancomycin | glycopeptide | inhibition of cell wall synthesis | narrow spectrum; gram-positive | poorly |
Imipenem | β-lactam | inhibition of bacterial cell wall formation | broad spectrum; gram-positive and negative | poorly |
Cephalothin | β-lactam | inhibition of bacterial cell wall formation | broad spectrum; gram-positive and negative | poorly |
Neomycin | aminoglycosides | inhibition of protein synthesis in bacteria | broad spectrum; excellent for gram-negative | poorly |