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. Author manuscript; available in PMC: 2017 Jul 28.
Published in final edited form as: Prostaglandins Other Lipid Mediat. 2015 Feb 14;116-117:64–75. doi: 10.1016/j.prostaglandins.2015.01.004

Fig. 2.

Fig. 2

CYP2J2 suppressed Iso or Ang II-induced inflammatory response in hearts of mice. (A) and (C) NF-κB p65 nuclear translocation activity was increased in WT mice with Iso(A) or Ang II (C) infusion, and were reduced in Tr mice. Proteins were normalized to β-actin or LaminB. (B) and (D) Immunohistochemical analyses of mice hearts and number of MOMA-2-positive cells per mm2. Scale bar, 40 μm. (E) and (F) Gene expression and protein levels of IL-1β, IL-6, IL-10 and MCP-1 in LV analyzed by real-time polymerase chain reaction and ELISA. LV, left ventricle; WT, wild type mice; Tr, CYP2J2 transgenic mice; Iso, isoprenaline; Ang II, angiotensin II. n = 5 each group. *P < 0.05 vs. WT + saline, #P < 0.05 vs. WT + Iso or WT + Ang II.