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. 2017 Jul 12;6(1):1350088. doi: 10.1080/20013078.2017.1350088

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© 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Comparison between ex-miRNA and total plasma miRNA. (a) At least one miRNA (cfa-miR-181c) remained statistically significant for ex-miRNA at a false discovery rate (FDR) as low as 5% when comparing between dogs with and without signs of CHF. The number of significant miRNA dropped from 78 to 0 for total plasma miRNA for a FDR of ≤10%. (b) Hierarchical clustering of plasma exosomal and total plasma miRNA expressions using normalised C_q number for the individual dogs (green = higher expression, red = lower expression). Clustering shows closer association by source of miRNA and not by individual dogs. EX = ex-miRNA; Total = total plasma miRNA.