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. 2015 Jun 5;2(2):93–105. doi: 10.3390/medicines2020093

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© 2015 by the authors.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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(A) Primary Lineweaver-Burk Plot of CYP2D6 inhibition (competitive) by vinpocetine in HLM; (B) Inhibition constant (K_i) was determined by plotting the slope of the Primary Lineweaver-Burk Plot versus the concentration of vinpocetine. The data are represented as mean ± SD of triplicate incubations in HLM.