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. 2015 Jun 5;2(2):93–105. doi: 10.3390/medicines2020093

Table 1.

IC50 values of CYP3A4 inhibition. The data are represented as mean ± SD of three independent experiments.

Compound CYP3A4 (recombinant)
IC50 (µM) IC50 (µM) IC50
Co-incubation Pre-incubation Shift (Fold)
Vinpocetine 2.8 ± 0.98 5.1 ± 0.1 0.54
Ketoconazole 0.04 ± 0.001 0.05 ± 0.002 0.80
Troleandomycin 2.5 ± 0.8 0.42 ± 0.05 5.95