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. 2017 Jun 15;35(8):1973–1983. doi: 10.1002/stem.2645

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© 2017 The Authors STEM CELLS published by Wiley Periodicals, Inc. on behalf of AlphaMed Press

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Inositol hexakisphosphate kinase 1 (Ip6k1) deletion enhances mesenchymal stem/stromal cell (MSC) hematopoiesis‐support activity. (A): Methylcellulose colony forming assays using conditioned media from Ip6K1^+/+ versus Ip6k1 ^−/− MSCs. Data are mean ± SD (n = 3). **, p < .01 by analysis of variance (ANOVA) and Tukey post hoc test. (B): Conditioned media from Ip6K1^+/+ versus Ip6k1 ^−/− MSCs was concentrated 50‐fold and analyzed using Luminex‐based multiplex bead arrays. Data represent mean ± SD (n = 2). (A) is two‐way ANOVA with Tukey post hoc test (**, p < .001) and (B–D) are Student's t test (*, p < .05; **, p < .01). Abbreviations: BFU, blast forming unit; CFU, colony forming unit; E, erythroid; G, granulocyte; GEMM, granulocyte, erythrocyte, monocyte, megakaryocyte; GM, granulcoyte, monocyte; M, monocyte; IL‐6, interleukin‐6; IP6K1, inositol hexakisphosphate kinase 1; SCF, stem cell factor; SDF, stromal derived factor; VEGF, vascular endothelial growth factor.