Table 1.

Na⁺, O₂, and glucose and lactate transport parameters.

Parameters	Value
Na+ transport
Maximum active Na+ transport rate (Vmax,i,Na)
Proximal straight tubule	2.1 nmol/cm2/s [31]
Thick ascending limb (outer stripe)	10.5 nmol/cm2/s [31]
Thick ascending limb (inner stripe)	25.9 nmol/cm2/s [31]
Collecting duct (outer stripe)	1.0 nmol/cm2/s [31]
Collecting duct (inner stripe)	1.6 nmol/cm2/s [31]
Collecting duct (initial IM)	8.5 nmol/cm2/s [28]
Collecting duct (terminal IM)	3.0 nmol/cm2/s [28]
Tubular capacity for anaerobic transport $(F_{\text{AN}}^i)$
Proximal straight tubule	0.14 [7]
Thick ascending limb	0.1 [1]
Collecting duct (OM)	0.5 [50, 53]
Collecting duct (IM)	0.4 [45]
O2 transport
Maximum basal O2 consumption rate $(R_{\max ,{\mathrm{O}}_2}^{\text{basal}})$	10 μM/s[3]
PO2 threshold for aerobic respiration (Pi,c)	10 mmHg [16]
Number of moles of Na+ transported per mole of O2 consumed (TQi)
Proximal straight tubule	18 [36, 52]
Thick ascending limb	18 [36]
Collecting duct	12 [52]
Capillary and tubular wall O2 permeability	0.04 cm/s [4]
Glucose and lactate transport
Maximum basal glucose consumption rate $(R_{\max ,G}^{\text{basal}})$	0.28 mM/s
Michaelis-Menten constant for basal glucose consumption (KM,G)	0.1 mM
Number of moles of Na+ transported per mole of glucose consumed
Aerobic (TQi,G,aerobic)	90†
Anaerobic (TQi,G,anaerobic)	6†
DVR wall glucose permeability	5.0 × 10−5 cm/s [55]
AVR wall glucose permeability	7.5 × 10−5 cm/s [55]
RBC membrane glucose permeability	1.0 × 10−5 cm/s [55]
DVR wall lactate permeability	1.0 × 10−4 cm/s [55]
AVR wall lactate permeability	1.6 × 10−4 cm/s [55]
RBC membrane lactate permeability	1.0 × 10−4 cm/s [55]

^†See text.