Figure 7.

Mice heterozygous for an Nrip1 null allele exhibit a spectrum of CAKUT phenotypes at E18.5. (A–L) Hematoxylin and eosin stainings of transverse sections of kidney and the ureter (A–C), kidney cortex (D–F), proximal ureter (G–I), and of sagittal sections of the embryonic bladder (J–L) from Nrip1^+/− E18.5 embryos. One of three Nrip1^+/− embryos analyzed exhibits a strong hydroureter, hydronephrosis, and ureterocele (middle panel). In two more specimens, kidneys are dysplastic and have microcystic dilations (right panel). c, cysts; k, kidney; p, pelvis; ts, tubular structures of the kidney; u, ureter; uc, ureterocele; ue, ureteric epithelium; um, ureteric mesenchyme.