Table 3.

Short-term ET receptor antagonism attenuates glomerular and tubular injury in HbSS mice

Variables	HbAA			HbSS
	Vehicle	Ambrisentan	A-182086	Vehicle	Ambrisentan	A-182086
Plasma ET-1, pg/ml	0.6±0.1	0.8±0.2	0.7±0.1	1.8±0.2a	1.0±0.1b	1.6±0.2a
Urinary protein excretion, mg/24 h	1.8±0.3	1.7±0.5	2.1±0.6	3.2±0.4a	2.4±0.3b	3.5±0.4a
Palb	0.12±0.02	0.13±0.02	0.12±0.02	0.48±0.05a	0.24±0.03b	0.27±0.04a,b
Urinary albumin excretion, μg/24 h	30.1±7.9	25.6±5.7	26.0±7.7	81.7±18.0a	35.2±6.2b	108.3±27.1a
Urinary nephrin excretion, ng/24 h	7.5±1.9	5.5±1.8	10.8±4.1	52.8±7.6a	31.6±2.1a,b	37.8±3.1a
Urinary KIM-1 excretion, pg/24 h	37±8	112±26	113±49	272±46a	122±22b	323±34a
Urinary NAG excretion, mU/24 h	9.4±1.6	5.4±2.7	6.4±2.8	40.2±8.3a	15.7±2.9b	27.5±7.1a

Data are means±SEM (n=12–14 in HbSS groups and n=6–9 in HbAA groups).

^aP<0.05 versus HbAA vehicle.

^bP<0.05 versus HbSS vehicle.