Table 1.
Baseline characteristics in incident patients as categorized on the basis of the baseline FO measurement
| Variables | Overhydrated (Men: FO≥15%, Women: FO≥13%) | Nonoverhydrated (Men: FO<15%, Women: FO<13%) | P Value | All Subjects |
|---|---|---|---|---|
| Patients, N | 18,371 | 21,195 | 39,566 | |
| Follow-up, d | 474±351 | 518±362 | <0.001 | 497±358 |
| Women/men, N (%) | 7144/11,227 (38.9/61.1) | 8829/12,366 (41.7/58.3) | <0.001 | 15,973/23,593 (40.4/59.6) |
| Age, yr | 61.0±15.5 | 60.8±15.9 | 0.32 | 60.9±15.7 |
| Height, cm | 165.4±9.8 | 164.5±10.0 | <0.001 | 164.9±9.9 |
| Weight predialysis, kg | 70.6±16.4 | 74.2±16.7 | <0.001 | 72.5±16.7 |
| Preweight − postweight, kg | 1.9±1.3 | 1.4±1.6 | <0.001 | 1.6±1.5 |
| BMI predialysis, kg/m2 | 26.1±16.3 | 27.9±20.2 | <0.001 | 27.1±18.5 |
| BP predialysis, mmHg | 146±26/75±15 | 138±24/73±14 | <0.001 | 142±25/74±15 |
| Treatment time, min | 233±34 | 232±38 | 0.03 | 232±36 |
| Patients on antihypertensive drugs, % | 54.8 | 51.4 | <0.001 | 53.0 |
| Patients with catheter, N (%) | 10,930 (59.5) | 10,168 (48.0) | <0.001 | 21,098 (53.3) |
| Patient smoking, N (%) | 3881 (21.1) | 4305 (20.3) | 0.05 | 8186 (20.7) |
| Ethnicity: white, N (%) | 15,103 (82.2) | 18,253 (86.1) | <0.001 | 33,356 (84.3) |
| Comorbidities | ||||
| Diabetes, % | 31.6 | 20.9 | <0.001 | 25.9 |
| Coronary artery disease, N (%) | 1258 (6.8) | 1183 (5.6) | <0.001 | 2441 (6.2) |
| Congestive heart failure, N (%) | 3555 (19.4) | 3051 (14.4) | <0.001 | 6606 (16.7) |
| Cerebrovascular disease (stroke), N (%) | 1987 (10.8) | 2246 (10.6) | 0.48 | 4233 (10.7) |
| Peripheral vascular disease, N (%) | 2232 (12.1) | 2096 (9.9) | <0.001 | 4328 (10.9) |
| Dementia, N (%) | 157 (0.9) | 130 (0.6) | <0.01 | 287 (0.7) |
| Chronic bronchopulmonary disease, N (%) | 1304 (7.1) | 1338 (6.3) | 0.002 | 2642 (6.7) |
| Paraplegia, N (%) | 51 (0.3) | 56 (0.3) | 0.80 | 107 (0.3) |
| Liver disease, N (%) | 1393 (7.6) | 1384 (6.5) | <0.001 | 2777 (7.0) |
| Connective tissue disorder, N (%) | 301 (1.6) | 263 (1.2) | <0.001 | 564 (1.4) |
| Biochemical measurements | ||||
| Hb, g/dl | 9.5±1.7 | 10.3±1.7 | <0.001 | 9.9±1.7 |
| Albumin, g/dl | 3.5±0.6 | 3.8±0.5 | <0.001 | 3.7±0.5 |
| Na, mmol/L | 137.8±4.6 | 137.7±4.2 | 0.65 | 137.8±4.4 |
| Phosphate, mg/dl | 4.6±1.7 | 4.8±1.7 | <0.001 | 4.7±1.7 |
| LDL cholesterol, mg/dl | 97.8±55.1 | 100.9±155.7 | 0.02 | 99.5±120.0 |
| HDL cholesterol, mg/dl | 42.8±16.7 | 40.8±15.4 | <0.001 | 41.7±16.1 |
| CRP, mg/L | 20.2±38.8 | 15.8±31.1 | <0.001 | 17.8±34.9 |
| Kt/V | 1.38±1.94 | 1.37±1.93 | 0.80 | 1.37±1.93 |
| PCRn, g/kg per d | 0.9±0.8 | 1.0±0.6 | <0.001 | 1.0±0.7 |
| FO predialysis, L | 4.8±2.8 | 0.9±1.5 | <0.001 | 2.7±2.9 |
BMI, body mass index; Hb, hemoglobin; Na, sodium; CRP, C-reactive protein; PCRn, normalized protein catabolic rate.