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. 2017 Jul 26;13:1744806917721114. doi: 10.1177/1744806917721114

Figure 1.

Figure 1.

Effects of acidosis on itch tachyphylaxis to SL-NH2. Itch-related behaviors in mice were determined by the number of scratching bouts in 5-min bins during a 30-min period following injection of pruritogens (as indicated) into the rostral back/neck in WT (filled symbols) and ASIC3-KO mice (open symbols). (a) First injection: SL-NH2 (7 mM) in saline (50 µl); second injection: SL-NH2 (14 mM) in saline (25 µl). (b) First injection: SL-NH2 (7 mM) and acid (0.6% acetic acid, v/v) in saline (50 µl); second injection: SL-NH2 (14 mM) and acid (1.2% acetic acid, v/v) in saline (25 µl). (c) First injection: SL-NH2 (7 mM) in saline (50 µl); second injection: SL-NH2 (14 mM) and acid (1.2% acetic acid, v/v) in saline (25 µl). (d) First injection: SL-NH2 (7 mM) and acid (0.6% acetic acid, v/v) in saline (50 µl); second injection: SL-NH2 (14 mM) in saline (25 µl). (e) First injection: SL-NH2 (7 mM) in saline (50 µl); second injection: acid (1.2% acetic acid, v/v) in saline (25 µl). (f) First injection: SL-NH2 (7 mM) and acid (0.6% acetic acid, v/v) in saline (50 µl); second injection: acid (1.2% acetic acid, v/v) in saline (25 µl). Data are means ± SEM; n = 8–11. N.S.: not significant difference, **P < 0.01, ***P < 0.001, first vs. second, paired Student’s t test. N.S.: not significant difference, #P < 0.05, ##P < 0.01, ###P < 0.001, WT vs. ASIC3-KO, unpaired Student’s t test.