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. 2017 Jul 26;13:1744806917721114. doi: 10.1177/1744806917721114

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© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — A hypothetical scheme for acid-mediated, ASIC3-dependent, counteraction of tachyphylaxis to successive pruritogenic itch. (Left) SL-NH₂ evokes itch via activation of MrgprC11 in sensory neurons; (middle) consecutive exposure of SL-NH₂ causes itch tachyphylaxis, likely due to the desensitization of MrgprC11 signaling cascades; (right) SL-NH₂ in the presence of acidosis activates ASIC3 in the same neuron, inducing itch via a different pathway, which counteracts tachyphylaxis and contributes to chronic itch.