Table 3.
Associations of rest-activity parameters and incident fracture, adjusted by age and clinic site
| Predictor | Model | Clinical Spine Fracture | Hip Fracture | Major Osteoporotic Fracture* | |||
|---|---|---|---|---|---|---|---|
| Events N (%) |
HR (95% CI) | Events N (%) |
HR (95% CI) | Events N (%) |
HR (95% CI) | ||
| Amplitude | Continuous per SD decrease (−1090 counts/min) Quintiles |
85 (2.83) | 1.29 (1.01, 1.66) | 110 (3.67) | 0.98 (0.81, 1.18) | 256 (8.53) | 1.09 (0.95, 1.25) |
| Q1:<2730.71 | 17 (2.83) | 1.71 (0.77, 3.79) | 21 (3.50) | 0.92 (0.48, 1.77) | 45 (17.58) | 1.13 (0.72, 1.78) | |
| Q2:2730.71 to <3315.83 | 20 (3.33) | 1.8 (0.84, 3.87) | 30 (5.00) | 1.36 (0.75, 2.45) | 65 (25.39) | 1.60 (1.06, 2.41) | |
| Q3:3315.83 to <3778.50 | 25 (4.17) | 2.34 (1.12, 4.91) | 20 (3.33) | 0.90 (0.47, 1.71) | 57 (22.27) | 1.41 (0.93, 2.15) | |
| Q4:3778.50 to <4361.92 | 13 (2.17) | 1.25 (0.55, 2.85) | 21 (3.50) | 1.03 (0.55, 1.93) | 53 (20.70) | 1.37 (0.90, 2.10) | |
| Q5:≥4361.92 | 10 (1.66) | reference | 18 (3.00) | reference | 36 (14.06) | reference | |
| P-trend | 0.13 | 0.80 | 0.44 | ||||
| Mesor | Continuous per SD decrease (−502 counts/min) Quintiles |
85 (2.83) | 1.14 (0.89, 1.45) | 110 (3.67) | 1.06 (0.87, 1.30) | 256 (8.53) | 1.07 (0.93, 1.22) |
| Q1:<1789.82 | 17 (2.83) | 1.4 (0.65, 3.02) | 32 (5.33) | 1.65 (0.91, 3.02) | 55 (21.48) | 1.30 (0.86, 1.97) | |
| Q2:1789.82 to <2030.22 | 25 (4.17) | 2.11 (1.04, 4.31) | 22 (3.67) | 1.14 (0.60, 2.15) | 58 (22.66) | 1.37 (0.91, 2.06) | |
| Q3:2030.22 to <2235.98 | 15 (2.50) | 1.29 (0.59, 2.81) | 20 (3.33) | 1.09 (0.57, 2.08) | 55 (21.48) | 1.34 (0.89, 2.02) | |
| Q4:2235.98 to <2500.61 | 17 (2.83) | 1.5 (0.70, 3.22) | 19 (3.17) | 0.98 (0.51, 1.89) | 49 (19.14) | 1.17 (0.77, 1.78) | |
| Q5:≥2500.61 | 11 (1.83) | reference | 17 (2.83) | reference | 39 (15.23) | reference | |
| P-trend | 0.23 | 0.07 | 0.16 | ||||
| Acrophase | Continuous per SD increase (1 hr, 12 min) Category |
85 (2.83) | 1.12 (0.90, 1.39) | 110 (3.67) | 0.97 (0.80, 1.18) | 256 (8.53) | 0.99 (0.87, 1.13) |
| <1:04PM | 13 (3.08) | 1.21 (0.66, 2.21) | 18 (4.27) | 1.26 (0.75, 2.11) | 42 (9.95) | 1.24 (0.88, 1.73) | |
| 1:04–3:29PM | 58 (2.67) | reference | 74 (3.41) | reference | 178 (8.21) | reference | |
| >3:29PM | 14 (3.41) | 1.47 (0.81, 2.64) | 18 (4.39) | 1.19 (0.71, 2.01) | 36 (8.78) | 1.08 (0.75, 1.55) | |
| Pseudo-F statistic | Continuous per SD decrease (−512.9) Quintiles |
85 (2.83) | 1.13 (0.88, 1.44) | 110 (3.67) | 1.19 (0.96, 1.48) | 256 (8.53) | 1.13 (0.98, 1.29) |
| Q1:<640.319 | 17 (2.83) | 1.60 (0.72, 3.55) | 22 (3.67) | 1.64 (0.80, 3.36) | 51 (19.92) | 1.32 (0.86, 2.04) | |
| Q2:640.319 to <853.460 | 14 (2.33) | 1.30 (0.57, 2.94) | 23 (3.83) | 1.72 (0.85, 3.48) | 46 (17.97) | 1.19 (0.76, 1.85) | |
| Q3:853.460 to <1092.75 | 22 (3.67) | 1.94 (0.92, 4.12) | 28 (4.67) | 2.20 (1.12, 4.34) | 65 (25.39) | 1.69 (1.12, 2.55) | |
| Q4:1092.75 to <1415.08 | 22 (3.67) | 1.95 (0.92, 4.14) | 25 (4.17) | 1.91 (0.96, 3.81) | 58 (22.66) | 1.49 (0.98, 2.27) | |
| Q5:≥1415.08 | 10 (1.66) | reference | 12 (2.00) | reference | 36 (14.06) | reference | |
| P-trend | 0.73 | 0.40 | 0.63 | ||||
HR, hazard ratio; CI, confidence interval; SD standard deviation.
*
Major Osteoporotic Fracture includes hip, wrist, shoulder, and clinical spine fracture.