Table 1. Baseline characteristics of high and low NF-κB activity groups.
| Characteristics | High NF-κB activity (n = 36) |
Low NF-κB activity (n = 47) |
P-value |
|---|---|---|---|
| Median age [years (IQR)] | 36.5 (26.3–42.5) | 36.0 (26.0–47.0) | 0.761 † |
| Median age at diagnosis [years (IQR)] | 24.5 (14.3–34.0) | 22.0 (17.0–30.0) | 0.787† |
| Sex | 0.206 § | ||
| Male [n (%)] | 23 (63.9) | 36 (76.6) | |
| Female [n (%)] | 13 (36.1) | 11 (23.4) | |
| Family history of CD [n (%)] | 0 (0.0) | 3 (6.4) | 0.254 ‡ |
| Extraintestinal manifestation [n (%)] | 2 (5.6) | 4 (8.5) | 0.693 ‡ |
| Oral stomatitis [n (%)] | 2 (5.6) | 3 (6.4) | 1.000 ‡ |
| Cutaneous manifestation [n (%)] | 0 (0.0) | 1 (2.1) | 1.000 ‡ |
| Ocular manifestation [n (%)] | 0 (0.0) | 1 (2.1) | 1.000 ‡ |
| Arthritis [n (%)] | 1 (2.8) | 2 (4.3) | 1.000 ‡ |
| Extent of disease | 0.028 § | ||
| L1 (terminal ileum) [n (%)] | 7 (19.4) | 21 (44.7) | |
| L2 (colon) [n (%)] | 1 (2.8) | 3 (6.4) | |
| L3 (ileocolon) [n (%)] | 28 (77.8) | 23 (48.9) | |
| L4 (upper gastrointestinal tract) [n (%)] | 0 (0.0) | 0 (0.0) | |
| Disease behavior at diagnosis | 0.589§ | ||
| B1 (NS-NP) [n (%)] | 20 (55.6) | 31 (66.0) | |
| B2 (stricturing) [n (%)] | 9 (25.0) | 8 (17.0) | |
| B3 (penetrating) [n (%)] | 7 (19.4) | 8 (17.0) | |
| Perianal lesion [n (%)] | 9 (25.0) | 22 (46.8) | 0.042 § |
| Smoking history [n (%)] | 4 (11.1) | 5 (10.6) | 1.000 † |
| Anti-tuberculosis medication | 0.293 § | ||
| Yes [n (%)] | 14 (38.9) | 11 (23.4) | |
| No [n (%)] | 4 (11.1) | 8 (17.0) | |
| Unknown [n (%)] | 18 (50.0) | 28 (59.6) | |
| Reason for primary operation | 0.767 § | ||
| Perforation [n (%)] | 10 (27.8) | 9 (19.1) | |
| Fistula [n (%)] | 8 (22.2) | 13 (27.7) | |
| Stricture [n (%)] | 14 (38.9) | 16 (34.0) | |
| Bleeding [n (%)] | 0 (0.0) | 1 (2.1) | |
| Intractable to medical therapy [n (%)] | 3 (8.3) | 7 (14.9) | |
| For diagnosis [n (%)] | 1 (2.8) | 1 (2.1) |
†Independent Student’s t-test
‡Fisher’s exact test
§Pearson’s chi square test