Fig 5. LXA₄-MS increased macrophages and IL-4 production.

(A) NAG (OD values) was quantified in skin ulcers collected on days 2, 7, and 14 from the vehicle (PBS/glue), Un-MS, soluble LXA₄, and LXA₄-MS groups (n = 5 ulcers/ group). (B) ELISAs were used to measure IL-4 production in skin ulcers collected on day 14 from the vehicle (PBS/glue), Un-MS, soluble LXA₄, and LXA₄-MS groups. Basal levels were also assessed. Data represent means ± SEM (n = 5 ulcers/ group). One-way ANOVA was done to determine statistical significance (p < 0.05) and indicated as follows: *, demonstrated significant differences compared to normal tissues (dashed line); ^#, LXA₄-MS vs. Vehicle (PBS/glue); ^$, LXA₄-MS vs. Un-MS; and ^&, LXA₄-MS vs. soluble LXA₄.