Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2005 Feb 24;102(10):3846–3851. doi: 10.1073/pnas.0500026102

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2005, The National Academy of Sciences

PMC Copyright notice

Fig. 3. — Neural tube defects and brain malformations in later-stage MEKK4-/- embryos. (A) An E14.5 MEKK4-/- embryo (Right) displayed cranial EX, SB, and CT. (B) Pictures of a MEKK4+/+ (Left) and two MEKK4-/- (i and ii) E18.5 embryos. Both MEKK4-/- embryos developed EX, and MEKK4-/-(ii) embryos also showed exposed eyes. (C and D) Nissl-stained coronal (C and E) and sagittal (D) sections of E18.5 MEKK4+/+ (Left) and MEKK4-/- (Right) brains. MEKK4-/-(i) embryo had a relatively normalsized FB but contained severely disrupted lateral ventricles (lv) and bilateral periventricular heterotopias (ph). These abnormal periventricular heterotopias structures disrupted continuities of the ventricular/subventricular zones (VZ/SVZ). In the MEKK4-/-(ii) embryo, the diencephalon (di) extended over the FB, which was small and rudimentary, but still possessed certain structures such as the hippocampus (hp). (E) At the level of the septal nucleus (sn), MEKK4-/-(i) FB showed severe morphological disruptions at the interhemispheric fissure (if) and corpus callosum (cc). (Bar,1 mm in C.)