Table 2. Materials available for review by the expert panel.

Material and Description	Link
Mutation Scores: For each ARV class, a table contained lists of individual DRMs and their associated scores, followed by a list of DRM combinations and their associated scores. Mutation penalty scores were multiples of 5 and ranged from -15 (increased ARV activity) to 60 (loss of ARV activity). ARV activity was estimated by adding the penalties for each DRM in a sequence and converting the total score to one of five interpretations: (i) “Susceptible”, total score <10; (ii) “Potential low-level resistance”, total score between 10 and 14; (iii) “Low-level resistance”, total score between 15 and 29; (iv) “Intermediate resistance”, total score between 30 and 59; and (v) “High-level resistance”, total score ≥60.	• https://hivdb.stanford.edu/dr-summary/mut-scores/NRTI/ • https://hivdb.stanford.edu/dr-summary/mut-scores/NNRTI/ • https://hivdb.stanford.edu/dr-summary/mut-scores/PI/ • https://hivdb.stanford.edu/dr-summary/mut-scores/INSTI/
Mutation Pattern Scores: A list of the calculated summed DRM penalty scores for each of the distinct DRM patterns present in HIVDB sequences.	• https://hivdb.stanford.edu/dr-summary/pattern-scores/NRTI/ • https://hivdb.stanford.edu/dr-summary/pattern-scores/NNRTI/ • https://hivdb.stanford.edu/dr-summary/pattern-scores/PI/ • https://hivdb.stanford.edu/dr-summary/pattern-scores/INSTI/
Mutation Classifications: (i) PR mutations were classified as “Major”, “Accessory”, or “Other; (ii) RT mutations were classified as “NRTI”, ‘NNRTI”, or “Other”; and (iii) IN Mutations were classified as “Major”, “Accessory”, or “Other”.	In the comments sections (below)
Mutation Comments: For each ARV class, there was a comment for each mutation with a penalty score and for several mutations without mutation penalty scores, which were once considered to be associated resistance.	• https://hivdb.stanford.edu/dr-summary/comments/NRTI/ • https://hivdb.stanford.edu/dr-summary/comments/NNRTI/ • https://hivdb.stanford.edu/dr-summary/comments/PI/ • https://hivdb.stanford.edu/dr-summary/comments/INSTI/
Mutation Notes: For each ARV class, there was an HTML page containing a summary of the DRMs associated with that class.	• https://hivdb.stanford.edu/dr-summary/resistance-notes/NRTI/ • https://hivdb.stanford.edu/dr-summary/resistance-notes/NNRTI/ • https://hivdb.stanford.edu/dr-summary/resistance-notes/PI/ • https://hivdb.stanford.edu/dr-summary/resistance-notes/INSTI/

ARV: antiretroviral; DRM: drug resistance mutation; NRTI: nucleoside RT inhibitor; NNRTI: nonnucleoside RT inhibitor; PI: protease inhibitor; INSTI: integrase strand transfer inhibitor