Table 9. In vitro susceptibilities associated with the 13 PI drug resistance mutation patterns.

Overall Pattern*	Specific Pattern*	%Exact†	%Included†	LPV§	ATV§	DRV§
N46IL	M46I	1.66%	32.22%	2.73	2.23	0.82
	M46L	1.79%	14.67%	1.62	2.41	0.71
L90M	L90M	7.43%	50.86%	1.642	3.133	0.919
M46I, L90M	M46I, L90M	1.38%	19.36%	2.723	4.917	0.86
M46I, I84V, L90M	M46I, I84V, L90M	0.43%	7.65%	1727	2219	44
M46L, I54V, V82A	M46L, I54V, V82A	0.41%	5.99%	3717	319	1.74
L76V¶	L76V¶	0.09%	4.15%	-	-	-
I50V	I50V	0.12%	2.63%	6.74	1.42	-
I54LM	I54L	0.15%	4.50%	4.61	1.71	3.61
	I54M	0.07%	3.74%	2.91	3.41	-
V32I, I47V	V32I, I47V	0.08%	4.17%	41	6.31	1.31
V32I, M46I, I47V, I84V	V32I, M46I, I47V, I84V	0.01%	0.75%	772	402	251
L33F, M46I, I47V, I54M, 84V, 90M	L33F, M46I, I47V, I54M, 84V, 90M	0.01%	0.02%	1756	746	>2003
V32I, L33F, M46I, I47V, I54M	V32I, L33F, M46I, I47V, I54M	0.01%	0.61%	-	-	-
L33F, M46L, I54M, I84V, V89I, L90M	L33F, M46L, I54M, I84V, V89I, L90M	0.00%	0.00%	431	-	-

*Mutation patterns are defined as those matching the listed mutations and not containing additional mutations at positions 30, 32, 46, 47, 48, 50, 54, 76, 82, 84, 88, and 90.

^†Exact: % of sequences exactly matching the mutation pattern; Included: % of sequences matching or including the mutation pattern.

^§Fold reduced susceptibility as determined by the PhenoSense assay (Monogram Biosciences, South San Francisco). Sequences with electrophoretic mixtures were excluded. “-”indicates that no phenotype results were available for a particular mutation pattern / PI combination. Fold reductions in susceptibility ≥3 for ATV, ≥9 for LPV, and ≥10 for DRV are in bold [5, 8, 9]. Fold reductions in susceptibility ≥6 for ATV, ≥40 for LPV, and ≥90 for DRV are also underlined [5, 8, 9].

^¶Of 67 LPV susceptibility results in HIVDB on viruses containing L76V, all had one or more additional DRMs.