Table 10. Patterns of relative INSTI susceptibility for 1,536 viruses in HIVDB with 209 distinct INSTI-Resistance patterns*.
| RAL | EVG | DTG | % of Total Relative INSTI Susceptibility Profiles† | Example DRM Patterns§ | DRM Pattern % with Profile | DRM Pattern % of Total | |
|---|---|---|---|---|---|---|---|
| Susc | Susc | Susc | 34.9 | E157Q | 65.7 | 22.9 | |
| T97A | 32.3 | 11.3 | |||||
| Q95K | 2.1 | 0.7 | |||||
| High | High | Int | 18.4 | G140S,Q148H | 66.7 | 12.3 | |
| G140S,Q148R | 3.5 | 0.6 | |||||
| E138K,Q148R | 3.2 | 0.6 | |||||
| High | High | Susc | 17.1 | N155H | 55.5 | 9.5 | |
| N155H,G163R | 12.5 | 2.1 | |||||
| N155H,E157Q | 12.2 | 2.1 | |||||
| Low | Low | Susc | 6.5 | G163R | 30 | 2.0 | |
| E138K | 21 | 1.4 | |||||
| G163K | 17 | 1.1 | |||||
| High | High | High | 5.3 | E138A,G140S,Q148H | 23.2 | 1.2 | |
| E138K,G140S,Q148H | 18.3 | 1.0 | |||||
| E138T,G140S,Q148H | 6.1 | 0.3 | |||||
| High | High | Low | 4.5 | E92Q,N155H | 23.2 | 1.0 | |
| Q148R | 14.5 | 0.7 | |||||
| Y143C,N155H,S230R | 7.2 | 0.3 | |||||
| High | Int | Susc | 3.4 | L74M,T97A,Y143R | 15.4 | 0.5 | |
| T97A,Y143C,S230R | 11.5 | 0.4 | |||||
| T97A,Y143R,G163R | 11.5 | 0.4 | |||||
| High | Low | Susc | 2.2 | T97A,Y143R | 58.8 | 1.3 | |
| L74M,Y143R | 20.6 | 0.5 | |||||
| T97A,Y143C | 8.8 | 0.2 | |||||
| Int | High | Susc | 1.8 | E92Q | 55.6 | 1.0 | |
| E92Q,T97A | 14.8 | 0.3 | |||||
| T66A,G163R | 7.4 | 0.1 | |||||
| High | Susc | Susc | 1.4 | Y143R | 71.4 | 1.0 | |
| Y143C | 9.5 | 0.1 | |||||
| Y143S | 9.5 | 0.1 | |||||
| Low | Int | Low | 1.2 | R263K | 94.4 | 1.1 | |
| E157Q,R263K | 5.6 | 0.1 | |||||
| High | Int | Low | 1 | L74M,T97A,Y143C,S230R | 25 | 0.3 | |
| L74I,T97A,Y143C,S230R | 12.5 | 0.1 | |||||
| Y143C,G163R,S230R | 12.5 | 0.1 | |||||
*Obtained from HIVDB (https://hivdb.stanford.edu/dr-summary/pattern-scores/INSTI/) January 2017. For the purposes of this analysis, the HIVDB interpretations of “Susc” and “Potential Low resistance” were grouped together as “Susc”.
†Relative susceptibility patterns accounting for ≥1% of all such patterns are shown. These patterns account for the HIVDB interpretations of 97.7% of sequences containing ≥1 INSTI DRM.
§For each relative INSTI susceptibility pattern, the three most common INSTI DRM patterns responsible for the relative susceptibility pattern are shown as examples.