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. 2017 Jul 28;12(7):e0182166. doi: 10.1371/journal.pone.0182166

Fig 3. PKM2 inhibition disrupts the energy shift in ovarian cancer cells and suppresses ovarian cancer cell growth.

Fig 3

(A) The ECAR according to Seahorse analysis decreased following shikonin treatment in SKOV3 and CP70 cells (*p<0.05). (B) PKM2 inhibition induced a shift in OCR/ECAR in SKOV3 cells. (C) Dose-dependent inhibition of cancer cell growth in CP70 and SKOV3 cells following shikonin treatment. (D) Migration assay involving CP70 and SKOV3 cells following shikonin treatment. ECAR, extracellular acidification rate; OCR, oxygen-consumption rate; PKM2, Pyruvate kinase M2.