Table 2. Univariate and multivariate Cox regression analysis for progression-free and overall survival in patients with ovarian cancer.
| Progression-free Survival | Overall Survival | |||
|---|---|---|---|---|
| Variable | Univariate analysis crude HR (95% CI) |
Multivariate adjusted HR (95% CI) a | Univariate analysis crude HR (95% CI) |
Multivariate adjusted HR (95% CI) d |
| Age (years) | 1.03 (0.99–1.06) | - | 1.05 (1.02–1.08) c | 1.03 (1.00–1.06) c |
| PKM2 expression b | ||||
| Low | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| High | 3.22 (1.22–8.48) c | 2.02 (0.70–5.85) | 1.19 (0.59–2.41) | 0.68 (0.33–1.40) |
| Stage | ||||
| I, II | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| III, IV | 16.07 (3.77–68.55) c | 21.71 (3.36–140.33) c | 26.25 (3.58–192.48) c | 13.23 (1.73–100.86) c |
| Grade | ||||
| Low | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| High | 4.16 (1.77–9.78) c | 1.90 (0.77–4.68) | 13.80 (4.15–45.87) c | 5.31 (1.56–18.07) c |
| Histologic type | ||||
| Serous type | 3.54 (1.07–11.74) c | 0.28 (0.05–1.46) | 1.67 (0.69–4.04) | - |
| Other types | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | - |
Abbreviations: HR, hazard ratio; CI, confidence interval
a The analysis adjusted for PKM2 expression, stage, grade, and histologic type
b The low expression of PKM2 regarding survival is represented as <50, and the high expression of PKM2 regarding survival is represented as > = 50.
c Significantly correlated with outcome, p < 0.05
d The analysis adjusted for age, PKM2 expression, stage, and grade