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Averaged over 7 days and over all control subjects (blue curve) and over all subjects with acute insomnia (red curve). Vertical gridlines at 6h intervals. Significant (p < 0.05) minute-to-minute differences are observed between the 2 groups for rest-to-wake (07:22–09:01) and wake-to-rest (23:01–24:00) transitions (orange shading).
