TABLE II.
Theoretical device sizing for scaled-up microfluidic artificial lungs. Published gas exchange and sizing data were used to scale up to a basis of 102 ml O2 exchange per min. Device dimensions are given as “diameter × length” for the rolled device, and “length × width × height” for planar devices. “N/A” signifies that data were not available for the calculation.
| Device design | Theoretical device size (cm3) | Gas exchange surface area (m2) | Device dimensions (cm) | 2D diffusion | Membrane thickness (μm) | Blood channel depth (μm) |
|---|---|---|---|---|---|---|
| Rolled device | 2411 | 0.66 | 15.2 × 14.2 | Yesa | 66 and 100 | 12 |
| Planar: Kniazeva11 | 4175 | N/A | 2.3 × 2.3 × 789 | No | 30 | 100 |
| Planar: Rieper19 | 9792 | 12.7 | 16 × 10 × 61.2 | Yes | 90 and 90 | 200 |
| Planar: (current design) | 5079 | 0.66 | 1.1 × 15.2 × 300 | No | 66 | 12 |
a
Calculated values do not take into account improvements in performance due to two-directional gas exchange in the rolled device and thus represent worst case values.